The year 2021 marks the 75th anniversary of UNESCO. This year also witnesses the continued fight against many global crises. As we endeavour to end the ongoing pandemic, the decisions we make will reshape human, economic, and environmental wellbeing for future generations. We need more urgent and ambitious actions in our society to end the pandemic, to secure an equitable and green recovery, and to speed up the implementation of the Sustainable Development Goals (SDGs). In this regard, we’d like to highlight some of UNESCO Beijing’s programmes and initiatives around SDGs for enhancing the resilience of cluster countries in the face of current global challenges with targeted actions on Education, Culture, Natural Sciences, Social and Human Sciences, Communication and Information.